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Rabbit-anti DKK1 monoclonal antibody
分类 信号转导
参数
货号:SLS-DKK1-01N
别名:DKK1,UNQ492/PRO1008
克隆号:5ZE9F
物种:Human
来源:Rabbit
免疫原:Recombinant human DKK1
识别位点:DKK1
亚型:Rabbit IgG
配对:No Conjugates
规格:25ug, 50ug, 100ug, >100ug/vial
浓度:>1mg/ml
状态和缓冲液:liquid,0.22μm filtered solution in 20mM hepes7.4, 150mm NaCl, 50% glycerin,0.03% proclin.
纯度:Greater than 95%, as determined by SDS-PAGE.
交叉反应:1.Hela cells were intracellularly-stained with SLS-DKK1-01N (red) or an isotype control (green), followed by SLS-7QK-01 goat anti-rabbit secondary antibodies. Non-fluorescently stained cells were used as blank control(black line).
2.Flow cytometry analysis of DKK1 overexpressed 293F cells with SLS-DKK1-01N , which was counjucated with SA-APC (red). The isotype control is green. The vertical axis indicates the antigen protein expression level.
保存条件:Stored at 2-8°C short term, -20°C or colder long term. Avoid multiple freeze/thaw cycles
用途:ELISA,FACS; Research Areas: Signal Transduction
使用建议:This product is only for the in vitro study, not intended for diagnostic use, please according to the laboratory standard operating procedures using.
实验照片
描述
Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6 . DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation.相关商品
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